ADNFarma

The Right Medication...The Right Dose

What is ADNFarma®?

ADNFarma® is a pharmacogenetic study, which studies the actions and interactions between drugs in each person at an individual level, based on their genome and their effects with respect to gene expression, being able to predict the efficacy and toxicity of drugs, thus allowing application of the appropriate therapy. Medications can cause adverse reactions, resulting in significant morbidity, therapeutic failure and even mortality, as well as increased health costs.

In this report we present the results of your ADNFarma® genetic analysis based on your genotype. The report contains information on genetic variants that we found in your genome and that have been associated with drugs used to treat a large number of common medical conditions.

Take into account that the results of this genetic analysis do not contain information for all the genetic variants so far known in the human genome. This is because new variants associated with specific health conditions are continually being discovered in ongoing research studies and the constant discovery of new drugs that are not yet on the market. In this comprehensive pharmacogenetic study we analyze genetic variants distributed in your 23 pairs of chromosomes and that metabolize drugs of interest.

Do medications work better based on your metabolism?

When a drug is administered, a process of absorption, distribution, interaction with its substrate, metabolization, and excretion begins. Each of these steps is mediated by the action of proteins in which there may be variations, resulting in different responses in each patient. The identification of the underlying genetic variations allows us to prescribe the most appropriate treatment in each case.

What drugs are reported in ADNFarma®?

In addition to those that are of interest to the patient and the doctor, an extensive list of drugs associated with different categories is annexed, from psychiatric, oncological to general/common use drugs.

Cardiology

Acenocumarol	Dofetilide	Nebivolol
Aliskiren	Dronedarone	Nifedipine
Amiodarone	Eplerenone	Nisoldipine
Amlodipine	Flecainide	Prasugrel
Atorvastatin	Guanabenz	Pravastatin
Azilsartan	Hydralazine	Propafenone
Carvedilol	Hydrochlorothiazide	Propranolol
Cerivastatin	Isosorbide dinitrate	Ranolazine
Cilostazol	Labetalol	Rosuvastatin
Clonidine	Lidocaine	Simvastatin
Clopidogrel	Losartan	Ticagrelor
Diltiazem	Lovastatin	Timolol
Disopyramide	Metoprolol	Verapamil

General

Articaine

Cyclobenzaprine

Diclofenac

Dipyrone (Metamizol)

Epinephrine

Fentanyl

Hydrocodone

Ibuprofen

Keterolac

Meloxicam

Methadone

Oxycodone

Tramadol

infectious diseases

Atazanavir	Fosamprenavir	Raltegravir
Boceprevir	Indinavir	Saquinavir
Darunavir	Itraconazole	Telaprevir
Dolutegravir	Nelfinavir	Telithromycin
Efavirenz	Nevirapine	Terbinafine
Erythromycin	Quinine Sulfate	Voriconazole

Hematology

Apixaban

Avatrombopag

Eltrombopag

Lusutrombopag

Rivaroxaban

Warfarin

gastroenterology

Aprepitant

Dexlansoprazole

Drospirenone

Esomeprazole

Lansoprazole

Metoclopramide

Omeprazole

Ondansetron

Palonosetron

Pantoprazole

Rabeprazole

antibiotics

Amoxicillin

Clarithromycin

Clindamycin

Psychiatry

Alprazolam	Doxepin	Paroxetine
Amitriptyline	Duloxetine	Perphenazine
Amoxapine	Escitalopram	Pimozide
Amphetamine	Fluoxetine	Pitolisant
Aripiprazole	Fluvoxamine	Protriptyline
Atomoxetine	Haloperidol	Quetiapine
Brexpiprazole	Iloperidone	Risperidone
Bupropion	Imipramine	Selective serotonin-reuptake inhibitors (SSRIs)
Buspirone	Lorazepam	Sertraline
Cariprazine	Midazolam	Thioridazine
Citalopram	Mirtazapine	Trazodone
Clomipramine	Nefazodone	Trimipramine
Clonazepam	Nicotine	Venlafaxine
Clozapine	Nortriptyline	Vortioxetine
Desipramine	Olanzapine	Ziprasidone
Desvenlafaxine	Oxazepam	Zuclopenthixol
Diazepam	Paliperidone

Gynecology

Elagolix

Etinilestradiol

Flibanserin

Sex hormones and modulators of the genital system

Ospemifene

Pneumology

Arformoterol

Dexamethasone

Fluticasone

Formoterol

Indacaterol

Isoniazid

Salmeterol

Sildenafil

Tadalafil

Tiotropium

Umeclidinium

nephrology

Sirolimus

Urology

Darifenacin

Fesoterodine

Finasteride

Mirabegron

Oxybutynin

Tamsulosin

Tolterodine

Vardenafil

Endocrinology

Chlorpropamide

Glimepiride

Glyburide

Nateglinide

Tolbutamide

Neurology

Amifampridine	Dextromethorphan	Meclizine
Brivaracetam	Donepezil	Phenytoin
Cafergot	Eletriptan	Quinidine
Clobazam	Galantamine	Tetrabenazine
Deutetrabenazine	Lacosamide	Valbenazine

Oncology

Axitinib	Erdafitinib	Paclitaxel
Belinostat	Erlotinib	Pazopanib
Binimetinib	Etoposide	Rucaparib
Bosutinib monohydrate	Exemestane	Sorafenib
Brentuximab vedotin	Fluorouracil	Sunitinib
Cabazitaxel	Gefitinib	Tamoxifen
Capecitabin	Ibrutinib	Tegafur
Cisplatin	Irinotecan	Temsirolimus
Dasatinib	Lapatinib	Thioguanine
Docetaxel	Mercaptopurine	Tropisetron
Dolasetron	Methotrexate	Vemurafenib
Enzalutamide	Nilotinib	Vincristine

Immunology

Azathioprine

Carisoprodol

Celecoxib

Cyclosporine

Everolimus

Flurbiprofen

Lesinurad

Piroxicam

Siponimod

Sirolimus

Tacrolimus

Rheumatology

Cevimeline

Colchicine

Tofacitinib

Others...

Atovaquene

Codeine

Eliglustat

Eszopiclone

Hydroxychloroquine

Lofexidine

Loratadine

Modafinil

Tafenoquine

Triazolam

Zolpidem

Icon	Description
	Extensive Metabolizer – Normal The drug is metabolized at the normal rate, meaning that the patient responds as expected with the standard dose.
	intermediate metabolizer The drug is metabolized at a slower rate than extensive metabolizers (≈50% of usual) = 50% EFFICACY. The drug can be administered, but: 1. If it is Active Drug in doses 50% lower than usual. 2. If it is Prodrug in 50% higher doses, although in this case it is more advisable to look for a therapeutic alternative.
	ultra-rapid metabolizer The drug is metabolized at a much higher rate than usual. The body transforms the drug into an eliminable form very quickly, eliminating it from the body very quickly and remaining for a very short time, experiencing very small and probably sub-therapeutic effects, with Therapeutic Failure being very likely. The body transforms the prodrug to its active form very quickly, the body having the active form in a shorter time, but what will determine the effect of the drug will be the elimination of the active form, in general the usual dose can be maintained, that is It is possible that with clinical data it can be specified more accurately in each case. Poor Metabolizer The drug is metabolized very slowly, it is practically not metabolized (0-10% of the usual). PM + Active Drug: The body is not capable of transforming the drug into an eliminable form (or it will do so very slowly), resulting in its concentration and increasing blood levels, thus causing an Overdose. PM + Prodrug: The body is not able to transform the Prodrug to its active form (or it will do so very slowly), resulting in increased prodrug levels, while active form levels will be reduced, thus causing Therapeutic Failure .

What are the factors that affect the variability of response to drugs?

There is great variability in how patients respond to drugs, in the occurrence of side effects, and in symptoms caused by drug toxicity. The variation depends on factors such as age, sex, liver and kidney function, and genetic factors. The inter-individual variations that affect the enzymes responsible for metabolizing drugs allow us to differentiate between four types of patients depending on the pharmacological treatment:

Normal metabolizers
Ultra-rapid metabolizers
Intermediate metabolizers
Slow metabolizers

In this report we show you the type of drug metabolism that you present according to the genotypes present in your genes.

What genes do we analyze at ADNFarma®?

We analyzed more than 24 genes and 106 variants directly involved in drug metabolism, the most important being the cytochromes (CYPs). Thus describing your metabolic capacities by category (ultra-fast, normal, intermediate and poor).

The Cytochrome P-450 Enzyme plays a very important role in the metabolism of toxicological elimination of drugs from the body. Some of these reactions are of great physiological importance, as they are key transformations in metabolism, such as lipid metabolism and corticosteroid biosynthesis. More than 53 cytochrome P-450 enzymes are found in humans. Such enzymes are molecularly promiscuously active due to the diversity of reactions they catalyze.

Due to the importance of this enzyme in Genolife, we take the 8 most important genes associated with the metabolism of this enzyme which are; CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, in which we analyzed more than 40 variants only for this metabolism.

ADNFarma®: Meet an alternative for your Oncological and Psychiatric treatments

Due to the complexity and inaccuracy of psychiatric treatments derived from different environmental factors that could influence human behavior, as well as varied and expensive cancer treatments, at GenoLife we have given ourselves the task of being able to help you choose more accurately through the molecular study of ADNFarma ®.

How do we carry out your ADNFarma® study?

Using just a small sample of saliva from the patient’s mouth, we can give you access to your DNA information.

We use the Global Screening Array Chip (Illumina®) in the 24 format, which consists of a panel of markers to detect genetic variants, most of which are selected by world experts and others are carefully chosen by Mexican researchers for the population Mexican. The interpretation of the genetic variants has been carried out by Genolife Life Information.

At GENOLIFE we are seriously committed to your health and apply the most advanced technologies for genetic studies.

How will I see my results in ADNFarma®?

Download a sample report!

This document provides an example of how your results are reported, the genotypes you present, as well as a list of medications according to your metabolism capacity.

Download

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