Intolerance to gluten (celiac disease)

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It is a multifactorial autoimmune disease manifested as gluten intolerance, involving both genetic and environmental factors.
Celiac disease affects both adults and children
Some genes have variants that confer an increased susceptibility to developing the disease. The most important related genes are HLA-DQA1 and HLA-DQB1. Other related genes are (IL21, IL18RAP, RGS1, SH2B3, MY098 and IL10) also contribute to the risk of suffering the disease.
The intake of foods with gluten causes a systemic reaction manifested by symptoms such as diarrhea, abdominal pain, inflammation, lactose intolerance, anorexia and weight loss.
Several diseases can mask the diagnosis of celiac disease, particularly inflammatory bowel disease, inflammatory bowel syndrome and tropical sprue.

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