Molecular Karyotype 60K, 180K, 400K.
The answer is in your genes
Molecular karyotype directed to autism
It detects 308 OMIM syndromes, regions associated with autism and other developmental disorders, as well as 140 genes specific for autistic spectrum disorders.
The Molecular Karyotype directed to Autism is a genetic test designed to detect in a single test the presence or absence of genetic alterations (deletions or duplications) throughout its genome.
This test is optimized for the detection of 308 OMIM syndromes (international database of genetic diseases). Where there are diseases related to autism and other developmental disorders. In addition, 140 specific genes of disorders within the autistic spectrum are reviewed.
Technique used What is an Array CGH?
The ARRAY CGH (Comparative Genomic Hybridization) is a genomic diagnostic technique used as a test of first choice in various pathologies of genetic origin. The ARRAY CGH allows to analyze, in a single test, the entire genome of an individual in search of alterations due to the gain or loss of genetic material.
How does an Array CGH work?
Alternatives offered by Genolife
- Molecular karyotype Array CGH 60k
- Molecular karyotype Array CGH 180k
- Molecular karyotype Array CGH 400 k
Molecular karyotype (Array-CGH 180K)
- 308 OMIM syndromes and regions of interest
- Recommended for intellectual disability and polymalformative syndromes
- Average detection capacity of the syndromic regions: 15 kb
- Coverage of critical genes in the syndromic regions: 1 probe every 3 kb
- Average detection capacity in the rest of the genome: 100 kb (more than 50 times the resolution of the conventional karyotype)
AUTISM Molecular Karyotype (Array-CGH 180K)
- 308 OMIM syndromes, 45 syndromes related to autism and 115 genes related to autism
- Recommended for intellectual disability and polymalformative syndromes
- Average detection capacity of the syndromic regions: 15 kb
- Coverage of critical genes in the syndromic regions: 1 probe every 3 kb
- Average detection capacity in the rest of the genome: 100 kb (more than 50 times the resolution of the conventional karyotype)
Molecular karyotype (Array-CGH 60K)
- 308 OMIM syndromes and regions of interest
- Recommended for intellectual disability and polymalformative syndromes
- Average detection capacity of the syndromic regions: 100 kb
- Minimum coverage of critical genes in the syndromic regions: 5 probes / gene (for genes larger than 50kb, the detection capacity is 50kb)
- Average detection capacity in the rest of the genome: 350 kb (more than 10 times the resolution of the conventional karyotype).
Molecular karyotype (Array-CGH 400K)
- 308 OMIM syndromes and regions of interest
- Average detection capacity in the rest of the genome: 25 kb (more than 200 times the resolution of the conventional karyotype).
- Detects simultaneously the presence or absence of genetic and chromosomal alterations (duplications / deletions) responsible for genetic syndromes. This array is especially indicated for studies that require a high resolution in the complete analysis of the genome, being able to simultaneously detect deletions that affect fragments of a single gene.
- Recommended for neurological disorders, intellectual disability and polymalformative síndromes
When is this study recommended?
The molecular karyotype (ARRAY-CGH) is recommended for the diagnosis of:
- Abnormalities and multiple malformations associated or not to a well-defined syndrome.
- Intellectual disability and non-syndromic development.
- Alterations of the autistic spectrum.
- Neurological and polymalformative disorders